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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Cancer Prev Res (Phila). 2010 May 18;3(6):718–726. doi: 10.1158/1940-6207.CAPR-10-0048

Fig. 1.

Fig. 1

A, immunoblotting for total and phospho-(Ser15)-p53 using lysates from MCF-7 cells treated with DMSO (control) or BITC (2.5 and 5.0 µmol/L) for the indicated time periods. B, immunoblotting for p53 using lysates from MCF-7 cells transfected with a control nonspecific siRNA or a p53-targeted siRNA, and treated for 24 h with DMSO (control) or 5.0 µmol/L BITC. C, cytoplasmic histone-associated apoptotic DNA fragmentation in MCF-7 cells transiently transfected with a control nonspecific siRNA or a p53-targeted siRNA, and treated for 24 h with DMSO (control) or 5.0 µmol/L BITC). Columns, mean (n= 3); bars, SD. *Significantly different (P<0.05) compared with nonspecific siRNA transfected cells treated with DMSO by one-way ANOVA followed by Bonferroni’s test. The results were consistent in two independent experiments, and representative data from one such experiment are shown.