Fig. 3.
Immunoblotting for XIAP protein using lysates from MCF-7 (A) and MDA-MB-231 cells (C) transiently transfected with empty pcDNA3.1 vector or pcDNA3.1 vector encoding for XIAP, and treated for 24 h with DMSO (control) or 5.0 µmol/L BITC. The numbers above the immunoreactive bands represent change in protein level relative to empty vector-transfected cells treated with DMSO (first lane). Cytoplasmic histone-associated apoptotic DNA fragmentation in MCF-7 (B) and MDA-MB-231 cells (D) transiently transfected with empty pcDNA3.1 vector or vector encoding for XIAP, and treated for 24 h with DMSO (control) or 5.0 µmol/L BITC. Columns, mean (n= 3); bars, SD. Significantly different (P<0.05) compared with empty vector-transfected cells treated with DMSO (a), and empty vector-transfected cells treated with BITC (b) by one-way ANOVA followed by Bonferroni’s test. Comparable results were observed in two independent experiments. Representative data from one such experiment are shown.
