Table 3.

Accuracy of VLS in single receptor mode measured by their ROC AUC values

Receptor	PDB ID	ROC %	Receptor	PDB ID	ROC %	Receptor	PDB ID	ROC %
ERα−	1xp6	71	PR+	1zuc_b	60	PPARα+	2npa_c	88
	1xqc_c	82		1e3k_a	75		2p54	78
	1sj0	73		2ovh	88		2rew	83
	2ouz	89	RARγ+	1exa	97		1k7l_a	92
ERα+	2b1v_a	85		1fcx	96	PPARδ+	1y0s_a	95
	2fai_a	80		2lbd	95		1gwx_a	97
	1l2i_a	81	RXRα+	2p1u	90		2j14_b	99
	2b1z_a	80		1rdt	92	PPARγ+	1rdt	89
ERβ-	1hj1	90		1mzn	88		1nyx	86
	1qkn	75		1fm9	86		1k74	89
	1qkm	61		1xvp	92		1knu	90
ERβ+	1u3r_a	96	VDR+	1db1	96		2f4b	87
	1yy4_a	98		1txi	78		2gtk	91
	1zaf_b	97		2has	97	TRβ+	2h6w	93
GR+	1m2z_a	80		1s19	76		1n46_b	93
	1p93_a	75		2har	76		1q4x	93
	3bdq	65		2hb7	92		1nax	91
wtMR+	2aa7	98	wtAR+	2hvc	81
	2a3i	96		1e3g	81
	2aa2	99		1t7t	87
S810LMR+	1y9r_a	80		2am9	83
	1ya3_a	95	T877AAR+	1gs4	89
	2aa6_a	91		2oz7	87
	2aax_a	93		2ax7	87

The crystal structure 1rdt is a heterodimer of PPARγ and RXRα and was used separately for both receptors