Figure 1.
C57BL/6 and BALB/c strains differ in response to hindlimb ischemia (HLI) (A). Hindlimb ischemia was induced, and perfusion was measured by laser Doppler perfusion imaging in C57BL/6 and BALB/c mice. Representative laser Doppler perfusion images of mice before surgery, immediately after surgery, and 3 weeks into recovery are shown. B, BALB/c mice are more prone to development of necrosis after induction of limb ischemia. Picture shows C57BL/6 and BALB/c mice, with BALB/c mice showing necrosis 1 week after hindlimb ischemia.