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. Author manuscript; available in PMC: 2010 Jun 5.
Published in final edited form as: Circulation. 2008 Feb 19;117(9):1207–1215. doi: 10.1161/CIRCULATIONAHA.107.736447

Figure 6.

Figure 6

A, A/J mice display poor recovery (BALB/c-like phenotype) after hindlimb ischemia. Hindlimb ischemia was induced, and perfusion was measured by laser Doppler perfusion imaging in A/J (n=15) and C57BL/6 (n=17) mice. No difference in perfusion was noted between the 2 strains immediately after induction of hindlimb ischemia (P>0.05); however, C57BL/6 showed better perfusion than A/J strain (P<0.01) at later time points. B, C57BL/6 chromosome 7 is required for its limb salvage phenotype after hindlimb ischemia. Hindlimb ischemia was induced in C57BL/6 (n=41), A/J (n=17), and CSS C57BL/6J-Chr7A/J/NaJ (n=10), which is genetically identical to C57BL/6 except at chromosome 7, which is A/J derived. Recovery was similar in CSS and A/J strains (P>0.05) but different in C57BL/6 (P<0.01).

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