Figure 2.

CD4⁺ T cell responses to framework and CDR-sequence-containing peptides derived from cetuximab (A) and humanized cetuximab (B) V regions. (A) 15-mer peptides overlapping by 12 amino acids describing the VH and VL regions of cetuximab were tested for their ability to induce proliferative responses with CD4⁺ cells and dendritic cells from 87 community donors. (B) peptides derived from humanized cetuximab were tested with 106 community donors. Framework sequence peptides are depicted by the open circles. CDR sequence-containing peptides are depicted by the black squares.