Table 2.

Relative risk of stroke by smoking status and gender

	Stroke Incidence			Stroke Mortality
	Never	Former	Current	Never	Former	Current
Total
Person-years of follow-up (per 100,000)	677210	22139	389707	692239	23606	399572
Number of events	3788	190	2802	2285	156	1538
Age-standardized rate per 100,000 person-years	445.1	470.7	622.9	257.1	335.7	344.1
Age and sex adjusted RR (95% CI)	1.00	1.13 (0.97-1.31)	1.22 (1.16-1.29)	1.00	1.25 (1.05-1.47)	1.17 (1.09-1.25)
Multivariate adjusted RR* (95% CI)	1.00	1.03 (0.89-1.20)	1.25 (1.18-1.33)	1.00	1.03 (0.87-1.22)	1.14 (1.06-1.23)
Male
Person-years of follow-up (per 100,000)	192896	18586	319104	198936	19821	326847
Number of events	1456	167	2246	914	139	1247
Age-standardized rate per 100,000 person-years	552.6	496.4	656.6	324.6	367.8	371.0
Age adjusted RR (95% CI)	1.00	1.19 (1.01-1.41)	1.24 (1.16-1.33)	1.00	1.33 (1.10-1.59)	1.17 (1.07-1.28)
Multivariate adjusted RR (95% CI)	1.00	1.07 (0.91-1.26)	1.28 (1.19-1.37)	1.00	1.08 (0.89-1.30)	1.13 (1.03-1.25)
Female
Person-years of follow-up (per 100,000)	484315	3553	70603	493303	3785	72725
Number of events	2332	23	556	1371	17	291
Age-standardized rate per 100,000 person-years	397.1	506.7	565.6	226.2	175.5	287.9
Age adjusted RR (95% CI)	1.00	0.88 (0.59-1.34)	1.20 (1.09-1.32)	1.00	0.94 (0.58-1.53)	1.18 (1.04-1.35)
Multivariate adjusted RR (95% CI)	1.00	0.86 (0.57-1.29)	1.25 (1.13-1.37)	1.00	0.86 (0.53-1.39)	1.19 (1.04-1.36)

^*Adjusted for baseline age, sex, education, cigarette smoking, alcohol consumption, physical inactivity, BMI, SBP, geographic region (north vs. south), urbanization (rural vs. urban), cardiovascular disease and the prevalence of diabetes at baseline as well as new onset diabetes during follow-up.