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. Author manuscript; available in PMC: 2010 Jun 5.
Published in final edited form as: Behav Pharmacol. 2002 Sep;13(5-6):379–388. doi: 10.1097/00008877-200209000-00011

FIGURE 2.

FIGURE 2

Time-dependent changes in resistance to extinction behavior and cue-induced reinstatement following withdrawal from cocaine (A) or sucrose (B). Mean (± SEM) number of responses on the previously active lever during the first six 60-min sessions of extinction [conducted in the absence of the discrete tone–light cue previously paired with cocaine infusions (A) or sucrose presentations (B)] and during the test for cue-induced reinstatement, which followed the extinction sessions. During the test for cue-induced reinstatement, lever presses led to presentations of the tone–light cue. Baseline: The last 60-min extinction session on which the rats reached the extinction criterion prior to the test for cue-induced reinstatement. *Significantly different from day1 withdrawal (Fisher PLSD test, P<0.05), n=9–11 per group. Data only include rats tested for both extinction responding and cue-induced reinstatement.