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Epidermal melanocytes (EM) and keratinocytes (K) produce prostaglandin E2 (PGE2) in response to H2O2. Hydrogen peroxide (50 μM for 24 h) increased PGE2 production in three of five primary EM cultures tested and in one keratinocyte culture tested. B (basal conditions), H2O2 (50 μM H2O2 for 24 h). Cell cultures: M20, 23, 37, 42, 48 and K. Error bars expressed as mean ± SEM (n = 3). P < 0.05 = *, P < 0.01 = **.
