Table 1.
Neuronal properties
| Age | mPSC | Genotype | Condition | Rise time (10–90%) (ms) | Decay time constant (τ, ms) | Ri (MΩ) | Rs (MΩ) |
|---|---|---|---|---|---|---|---|
| P11 | mEPSC | WT | NR (n = 12) | 1.4 ± 0.1 | 2.8 ± 0.2 | 569 ± 19 | 21 ± 1.0 |
| KO | NR (n = 13) | 1.4 ± 0.1 | 3.1 ± 0.2 | 510 ± 26 | 20 ± 1.0 | ||
| P23 | mEPSC | WT | NR (n = 16) | 1.5 ± 0.03 | 3.0 ± 0.1 | 455 ± 58 | 20 ± 0.9 |
| DR (n = 12) | 1.5 ± 0.03 | 3.0 ± 0.1 | 303 ± 41 | 18 ± 1.1 | |||
| +2hL (n = 16) | 1.6 ± 0.04* | 3.4 ± 0.2 | 371 ± 43 | 19 ± 1.1 | |||
| +1dL (n = 17) | 1.4 ± 0.04 | 2.9 ± 0.1 | 294 ± 42 | 16 ± 0.6 | |||
| KO | NR (n = 14) | 1.5 ± 0.03 | 3.2 ± 0.1 | 394 ± 57 | 20 ± 1.2 | ||
| DR (n = 14) | 1.5 ± 0.03 | 3.2 ± 0.1 | 329 ± 32 | 18 ± 1.6 | |||
| +2hL (n = 15) | 1.5 ± 0.03 | 3.3 ± 0.1 | 244 ± 15 | 17 ± 0.5 | |||
| +1dL (n = 14) | 1.6 ± 0.06 | 3.5 ± 0.2 | 341 ± 40 | 21 ± 0.7 | |||
| P23 | mIPSC | WT | NR (n = 17) | 1.9 ± 0.06 | 6.3 ± 0.2 | 265 ± 11 | 20 ± 0.9 |
| DR (n = 18) | 1.8 ± 0.06 | 6.8 ± 0.2 | 251 ± 9 | 18 ± 0.8 | |||
| +2hL (n = 14) | 1.7 ± 0.04 | 6.4 ± 0.2 | 268 ± 16 | 18 ± 0.6 | |||
| KO | NR (n = 15) | 1.8 ± 0.04 | 6.0 ± 0.1 | 250 ± 15 | 20 ± 1.1 | ||
| DR (n = 15) | 1.8 ± 0.05 | 6.3 ± 0.2 | 261 ± 21 | 20 ± 1.0 | |||
| +2hL (n = 15) | 1.8 ± 0.05 | 6.1 ± 0.2 | 257 ± 14 | 18 ± 0.9 |
*p < 0.05, statistically different from NR of the same genotype, Fisher's PLSD post hoc test after one-way ANOVA.