Skip to main content
. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Exp Gerontol. 2010 Jan 11;45(4):291–296. doi: 10.1016/j.exger.2010.01.001

Fig. 4. Regulation of BACE1 promoter following B12/folate or SAM supplementation.

Fig. 4

Methylation deficiency can be remediated by dietary supplementation with B12, folate, and/or SAM. This would drive the HCY/SAM cycle “forwards” and provide more abundant methyl groups for transfer to substrates such as CpG dinucleotides. Methylated CpG would permit binding of MDBP, which would inhibit binding of SP1. Inhibition of SP1 binding would regulate gene expression and reduce levels of BACE1 and amyloidogenesis.