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Potential versatility of Protacs. Any number of ligands or binding partners could be chemically linked to any peptide or small molecule that associates with any E3 ubiquitin ligase to promote the ubiquitination and degradation of a cancer-causing protein. Reprinted from Sakamoto KM et al. 2001 Proc Natl Acad Sci USA 98:8554–8559. Copyright © 2001, The National Academy of Sciences, with permission.
