Table 4.

Multivariate model of predictors of antiretroviral therapy reinitiation in the SMART drug conservation arm

	Univariate		Multivariate
	Hazard ratio	P-value	Hazard ratio	P-value
Non-HBV/HCV	1.00		1.00
HBV	1.95 (1.45–2.63)	<0.0001	1.71 (1.27 – 2.31)	0.0005
HCV	1.01 (0.87–1.18)	0.87	1.04 (0.88 – 1.22)	0.66
Prior AIDS	2.17 (1.91–2.45)	<0.0001	1.41 (1.24 – 1.61)	<0.0001
Nadir CD4 count (/100 cells lower)	1.67 (1.60–1.75)	<0.0001	1.50 (1.42 – 1.58)	<0.0001
Baseline CD4 count (/100 cells lower)	1.20 (1.16–1.23)	<0.0001	1.14 (1.11 – 1.18)	<0.0001
Baseline HIV RNA ≤400 copies/ml	1.18 (1.04–1.34)	0.011	1.19 (1.04 – 1.37)	0.012
Highest HIV RNA (Log10)	1.34 (1.25–1.44)	<0.0001	1.19 (1.11 – 1.28)	<0.0001
Female	0.97 (0.84–1.11)	0.61	1.01 (0.88 – 1.16)	0.89
Age (/10 years)	1.15 (1.08–1.22)	<0.0001	1.13 (1.06 – 1.20)	0.0003

Abbreviations: HBV, hepatitis B virus; HCV, hepatitis C virus; AIDS, acquired immune deficiency syndrome.