Fig. 1.

Our protocol for simultaneous fitting of component structures into density maps is divided into two stages. First, approximate positions of all components are determined at a coarse information level by our IQP point matching approach (upper grey shading). By varying the initial parameter settings, an ensemble of solutions is generated. At a second stage, all candidate structures are assessed and structurally refined using the initial density map and the density of the component structures simulated at the same resolution (lower grey shading).