Table 4.
Distribution, ORs, and 95% CIs for selected exposures in familial WM patients and their unaffected blood relatives
| Exposure | Frequency of reported exposure, no. (%) |
OR (95% CI)* |
LRT | |||||
|---|---|---|---|---|---|---|---|---|
| Multiple-case WM, n = 57† | Mixed WM/BCD, n = 46 | All familial WM, n = 103 | Unaffected relatives, n = 272 | Cases vs controls: multiple-case families | Cases vs unaffected: mixed WM/BCD families | All familial WM vs all controls | ||
| Smoking, ever | 30 (53.6) | 26 (57.8) | 56 (55.4) | 122 (45.2) | 1.41 (0.68-2.91) | 1.38 (0.70-2.73) | 1.36 (0.83-2.20) | 0.9 |
| Alcohol, ever | 46 (80.7) | 38 (82.6) | 84 (81.6) | 206 (76.0) | 2.21 (0.83-5.90) | 1.30 (0.49-3.48) | 1.74 (0.84-3.59) | 0.9 |
| Farming | 11 (19.6) | 10 (22.2) | 21 (20.8) | 24 (8.8) | 1.52 (0.70-3.31) | 5.52 (1.92-15.88)‡ | 2.70 (1.34-5.43)‡ | 0.06 |
| Pesticides | 9 (16.1) | 9 (19.6) | 18 (17.6) | 26 (9.6) | 2.22 (0.98-5.04) | 3.10 (1.31-7.35)‡ | 2.83 (1.56-5.11)‡ | 0.4 |
| Livestock | 10 (17.8) | 6 (13.3) | 16 (15.8) | 34 (12.6) | 1.06 (0.44-2.55) | 0.99 (0.35-2.83) | 1.07 (0.55-2.10) | 0.8 |
| Organic solvents | 14 (27.4) | 9 (20.4) | 23 (24.2) | 30 (12.2) | 4.21 (1.69-10.51)‡ | 1.14 (0.49-2.63) | — | 0.05 |
| Wood dust | 11 (23.4) | 7 (17.1) | 18 (20.4) | 28 (11.7) | 2.57 (1.09-6.06)‡ | 3.21 (1.16-8.85)‡ | 2.86 (1.54-5.33)‡ | 0.6 |
| Asbestos | 5 (11.1) | 5 (12.8) | 10 (11.9) | 9 (3.9) | 1.97 (0.41-9.56) | 4.88 (1.07-22.20)‡ | 2.64 (0.85-8.19) | 0.5 |
| Hair dye | 10 (21.3) | 8 (18.6) | 18 (20.0) | 38 (15.8) | 2.11 (0.96-4.66) | 1.16 (0.48-2.81) | 1.53 (0.83-2.82) | 0.5 |
| Radiation-related occupation | 2 (3.6) | 4 (8.9) | 6 (5.9) | 18 (6.8) | 0.58 (0.06-5.13) | 0.86 (0.26-2.82) | 0.74 (0.25-2.21) | 0.8 |
| Therapeutic radiation | 2 (3.5) | 2 (4.3) | 4 (3.9) | 21 (7.8) | 0.41 (0.08-1.99) | 0.16 (0.02-1.07) | 0.21 (0.05-0.81)‡ | 0.3 |
OR indicates odds ratio; CI, confidence interval; WM, Waldenström macroglobulinemia; BCD, B-cell disorder; LRT, likelihood ratio test; and —, no relevant data.
*
Accounting for familial clustering among relatives and adjusted for age, sex, and family type (in all familial WM models).
†
Numbers and percentages may not sum to total because of missing data and rounding, respectively. Percentages are based on nonmissing values.
‡
Parameters that differed significantly (P < .05) between groups. See “Results.”