Table 2.
NOS2A single marker association in African-Americans
| Rs # | SNP Typea | Allele Frequency (Allele) |
OR | 95% CI | Uncorrected p valueb |
|
|---|---|---|---|---|---|---|
| rs8073782 | Promoter | 0.80(C) / 0.20(T) | 0.91 | 0.65 | 1.27 | 0.57 |
| rs61589465 (T-5937C) | Promoter | 0.96(A) / 0.04(G) | 2.15 | 0.87 | 5.30 | 0.10 |
| rs57234985 (T-5091C) | Promoter | 0.96(A) / 0.04(G) | 0.44 | 0.22 | 0.91 | 0.03 |
| rs28998790 (G-1459A) | Promoter | 0.93(G) / 0.07(A) | 1.16 | 0.53 | 2.52 | 0.72 |
| rs57161411 (A-1641C) | Promoter | 0.99(A) / 0.01(C) | 0.67 | 0.20 | 2.18 | 0.50 |
| rs9282799 | Promoter | 0.94(G) / 0.06(A) | 0.96 | 0.48 | 1.93 | 0.91 |
| rs2779248 | Promoter | 0.53(T) / 0.47(C) | 1.03 | 0.78 | 1.37 | 0.83 |
| rs10459953 | 5′UTR | 0.70 (G) / 0.30(C) | 0.91 | 0.66 | 1.27 | 0.58 |
| rs2072324 | Intron | 0.88(C) / 0.12(A) | 0.93 | 0.56 | 1.55 | 0.79 |
| rs8072199 | Intron | 0.82(C) / 0.18(T) | 1.29 | 0.88 | 1.89 | 0.20 |
| rs3794764 | Intron | 0.71(G) / 0.29(A) | 0.74 | 0.52 | 1.05 | 0.09 |
| rs17722851 | Intron | 0.96(T) / 0.04(A) | 1.34 | 0.45 | 3.99 | 0.60 |
| rs2314812 | Intron | 0.84(C) / 0.16(T) | 1.00 | 0.67 | 1.50 | 0.99 |
| rs944725 | Intron | 0.51(C) / 0.49(T) | 0.78 | 0.57 | 1.08 | 0.13 |
| rs3730017 | Coding Exon (R/W 221) | 0.76(G) / 0.24(A) | 1.20 | 0.84 | 1.70 | 0.32 |
| rs3729508 | Intron | 0.83(C) / 0.17(T) | 1.76 | 1.16 | 2.67 | 0.01 |
| rs1113283 | Intron | 0.84(C) / 0.16(T) | 0.99 | 0.66 | 1.48 | 0.95 |
| rs9904158 | Intron | 0.94(G) / 0.06(C) | 1.23 | 0.60 | 2.54 | 0.57 |
| rs4795067 | Intron | 0.82(A) / 0.18(G) | 1.14 | 0.76 | 1.71 | 0.52 |
| rs1137933 | Coding Exon (D/D 346) | 0.85(G) / 0.15(A) | 1.00 | 0.66 | 1.52 | 1.00 |
| rs12944039 | Intron | 0.76(G) / 0.24(A) | 0.75 | 0.53 | 1.08 | 0.12 |
| rs16966545 | Intron | 0.83(T) / 0.17(A) | 0.84 | 0.55 | 1.31 | 0.45 |
| rs2314810 | Intron | 0.99(G) / 0.01(C) | 5.71 | 0.81 | 40.27 | 0.08 |
| rs17718148 | Intron | 0.88(C) / 0.12(T) | 1.03 | 0.64 | 1.68 | 0.89 |
| rs3729966 | Intron (boundary) | 0.86(C) / 0.14(T) | 0.75 | 0.48 | 1.18 | 0.22 |
| rs2248814 | Intron (boundary) | 0.83(G) / 0.17(A) | 1.68 | 1.13 | 2.50 | 0.01 |
| rs3729718 | Intron (boundary) | 0.94(T) / 0.06(G) | 0.48 | 0.28 | 0.85 | 0.01 |
| rs2274894 | Intron | 0.83(G) / 0.17(T) | 1.84 | 1.23 | 2.77 | 0.003 |
| rs9797244 | Intron | 0.83(T) / 0.17(C) | 0.92 | 0.63 | 1.36 | 0.68 |
| rs2297518 | Coding Exon (S/L 569) | 0.89(G) / 0.11(A) | 1.17 | 0.72 | 1.91 | 0.51 |
| rs2297516 | Intron | 0.66(A) / 0.34(C) | 0.77 | 0.54 | 1.09 | 0.15 |
| rs2314809 | Intron | 0.57(T) / 0.43(C) | 1.40 | 1.03 | 1.92 | 0.03 |
| rs2297515 | Intron | 0.97(A) / 0.03(C) | 1.80 | 0.64 | 5.05 | 0.27 |
| rs944722 | Intron | 0.79(T) / 0.21(C) | 1.63 | 1.14 | 2.33 | 0.01 |
| rs2255929 | Intron | 0.57(A) / 0.43(T) | 1.45 | 1.06 | 1.99 | 0.02 |
| rs3794756 | Intron | 0.91(C) / 0.09(T) | 0.71 | 0.42 | 1.18 | 0.19 |
| rs11653716 | Intron | 0.66(C) / 0.34(G) | 1.01 | 0.73 | 1.42 | 0.93 |
| rs7406657 | Downstream | 0.82(G) / 0.18(C) | 0.90 | 0.61 | 1.32 | 0.59 |
| rs7215373 | Downstream | 0.76(C) / 0.24(T) | 1.67 | 1.17 | 2.37 | 0.004 |
Statistically significant p values (p<0.05) are in bold; an allele frequencies are for founders; and all analyses were adjusted for age (years) and gender
a
SNPs type was determined using SNPper software available from http://snpper.chip.org
b
These p values are uncorrected for multiple comparisons