Table 3.

Hierarchical Linear Models of Evening and Morning Fatigue

Evening Fatigue	Coefficient (SE)
Variable	Unconditional Model	Final Model
Fixed Effects
Intercept	4.947 (0.214)**	4.644 (0.203)**
Timea (linear rate of change)	0.072 (0.218)*	0.120 (0.028)**
Time2 (quadratic rate of change)	−0.002 (0.0008)*	−0.004 (0.001)**
Time invariant covariates
Intercept:  Children at home		1.384 (0.427)*
CES-D score		0.089 (0.019)**
Linear:   Work × time		−0.105 (0.042)+
Quadratic:    Work × time2		−0.005 (0.002)*
Variance components
In intercept	2.979**	1.989**
In linear rate	0.015**	0.012**
In quadratic fit	0.00001*	0.00001+
Goodness-of-fit deviance(parameters estimated)	3154.432 (10)	3117.1853 (14)
Model comparison (χ2 [df])		37.247 (4)**
Morning Fatigue	Coefficient (SE)
Variable	Unconditional Model	Final Model
Fixed Effects
Intercept	2.940 (0.212)**	2.942 (0.155)**
Timea (linear rate of change)	0.049 (0.025)+	−0.093 (0.038)+
Time2 (quadratic rate of change)	−0.003 (0.001)*	−0.002 (0.001)
Time invariant covariates
Intercept:  Age		−0.034 (0.014)+
Body Mass Index		−0.054 (0.021)*
Trait anxiety score		0.038 (0.016)+
GSDS score		0.033 (0.008)**
Linear:   Number of co-morbidities × time		0.112 (0.042)+
Stage of disease × time		0.173 (0.0424)**
Quadratic:   Number of co-morbidities × time2		−0.004 (0.002)+
Stage of disease × time2		−0.006 (0.002)*
Variance components
In intercept	2.900*	1.389**
In linear rate	0.027*	0.014**
In quadratic fit	0.00003*	0.00001*
Goodness-of-fit deviance(parameters estimated)	3131.8235 (10)	3057.1598 (18)
Model comparison (χ2 [df])		74.664 (8)**

^aTime was coded 0 at the time of the simulation visit

^**p < 0.0001,

^*p < 0.01,

⁺p ≤ 0.05

Abbreviations: CES-D = Center for Epidemiologic Studies Depression Scale, GSDS = General Sleep Disturbance Scale, LFS = Lee Fatigue Scale, RT = radiation therapy