Table 2.
NNT Estimates for tPA Therapy Stratified by 90-Minute Treatment Time-Windows
| Treatment Time Window, Minutes | 0–90 | 91–180 | 181–270 | 271–360 |
|---|---|---|---|---|
| Expert panel | ||||
| 7-strata | ||||
| NNTB | 3.6 (3.1–4.2) | 4.3 (3.6–5.3) | 5.9 (4.3–8.2) | 19.3 (12.0–31.0) |
| NNTH | 65 (38–111) | 38 (24–61) | 30 (20–45) | 14.0 (10.5–17.8) |
| 6-strata | ||||
| NNTB | 3.7 (3.1–4.3) | 4.3 (3.6–5.3) | 5.9 (4.3–8.2) | 19.4 (12.1–31.0) |
| NNTH | 82 (42–160) | 49 (31–77) | 36 (24–53) | 16.1 (13.8–18.8) |
| Computer simulation | ||||
| NNTB | 3.4 (2.4–4.4) | 4.3 (3.1–5.5) | 6.7 (5.9–7.5) | 18.4 (14.0–22.7) |
| Maximum possible benefit | ||||
| NNTB | 2.0 | 2.9 | 3.9 | 12.1 |
| Minimum possible benefit | ||||
| NNTB | 6.7 | 7.0 | 9.7 | 30 |
| Median expert | ||||
| NNTB | 3.9 | 4.0 | 6.5 | 17 |
| NNTH | 71 | 37 | 33 | 13 |
Values are means and 95% CIs when applicable. The median NNTH distribution of all experts was used as a basis for computation of maximum and minimum possible NNTBs and for the computer-generated NNTB estimates. NNT estimates are based on shifts over the entire range of the mRS (7-strata) unless otherwise specified.