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. Author manuscript; available in PMC: 2010 Jun 7.
Published in final edited form as: J Antibiot (Tokyo). 2005 Jun;58(6):405–408. doi: 10.1038/ja.2005.51

Table 1.

IC50 values of jadomycin derivativesa

Cell lines IC50 (μM)b
1 2 3 4 5 6
HepG2 10.8 100 49 27 9.8 27
IM9 8.5 40 29 8.2 6.3 9.1
H460 21.8 30.7 12.4 NDb 19.2 19.6
a

Human cancer cell lines HepG2, IM9 and H460 were treated continuously with jadomycin derivatives for 24 hours. Cytotoxicity was determined by the MTT/MTS assay as described in the text.

b

IC50 was calculated from survival curves of at least three independent experiments. ND, not determined.