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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2009 Sep;124(3):496–506.e6. doi: 10.1016/j.jaci.2009.06.046

Figure 5. Reduced Threshold for Development of AD-Like Inflammation in Response to Repeated Ox Challenges in Flaky Tail Mice.

Figure 5

Flaky tail (FT) and wild-type (WT) mice were sensitized to Ox, and then repeatedly challenged with a subthreshold concentration of Ox (0.02%) every other day to a shaved area of back skin for a total of 10 challenges. Under basal conditions, FT mice display low-grade inflammation (F, see also suppl. Fig. 3C vs. A). FT skin displayed much more prominent erythema, scaling and excoriations than does WT mouse skin (see text), a change that is associated with a modest inflammatory infiltrate (B vs. A & suppl. Fig. 3C), that was enriched in CD3+ dermal lymphocytes (D vs. C). Quantitative changes in epidermal hyperplasia and inflammation are shown in E&F. G: Serum IgE levels are significantly elevated in most flaky tail mice, even under basal conditions. Mag bars = 40 µm.