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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2009 Sep;124(3):496–506.e6. doi: 10.1016/j.jaci.2009.06.046

Figure 6. Altered Sensitivity to Irritant/Hapten-Induced Allergic Contact Dermatitis in Flaky Tail Mice.

Figure 6

In young, wild-type mice, TPA induces irritant contact dermatitis, while Ox induces allergic contact dermatitis following a single, full-strength challenge dose 38. While higher concentrations produced comparable changes in young wide-type (WT) and flaky tail mice, lower doses of either TPA (A) or Ox (B) induce inflammation only in flaky tail mice. Changes in ear thickness correlate with severity of inflammation (see suppl Fig. 4).