Skip to main content
. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Eur J Neurosci. 2009 Dec 23;31(2):336–348. doi: 10.1111/j.1460-9568.2009.07065.x

Fig. 7.

Fig. 7

Hypocretin (HCRT) knockout (KO) mice display disrupted dopamine (DA) signaling and attenuated DA responses to cocaine. (A and B) The mean ± standard error of the mean of stimulated (A) DA release and (B) maximal uptake rate (Vmax) in wild-type (WT) (n = 7) and HCRT KO (n = 7) mouse slices containing the nucleus accumbens (NAc) core. (C) Shown are the mean ± standard error of the mean DA uptake inhibition (apparent affinity, Km) in WT (n = 7) and HCRT KO (n = 7) mouse slices across cumulative doses of cocaine. *P < 0.05 and **P < 0.01 relative to vehicle.