Table 1.

Baseline Characteristics of CHS Participants by Exposure to ACE Inhibitors N=1054, followed for 5255 person-years

	Ever ACE inhibitor	Never ACE inhibitor	P Value
	Mean(SD) or %	Mean(SD) or %
N	414	640
Age	74.5 (4.7)	75.0 (5.0)	0.10
Female	57.5	67.8	<0.001
White race	76.6	76.1	0.86
Education			0.57
<High School	25.9	27.2
=High School	31.6	28.6
>High School	42.5	44.2
Income (per year)			0.002
<$12,000	19.2	29.4
$12,000–35,999	57.2	50.3
≥$35,000	23.5	20.3
Smoking History			0.74
Never	47.1	49.4
Former	45.6	43.2
Current	7.4	7.3
Alcohol use			0.13
none	54.0	57.9
1–7 drinks/wk	33.9	33.7
>7 drinks/wk	12.1	8.5
3MSE score	92.5 (5.7)	92.0 (6.5)	0.06
CES-D Score	5.3 (4.9)	5.0 (4.7)	0.28
Creatinine (mg/dL)	1.1 (0.3)	1.0 (0.3)	0.01
C-Reactive Protein (mg/L)	5.7 (9.0)	5.8 (9.7)	0.88
LDL (mg/dL)	129.3 (35.1)	125.8 (32.5)	0.10
≥1 APOE-e4 allele	22.6	25.2	0.35
Diabetes			<.001
None	69.4	80.1
Impaired Fasting Glucose	8.0	8.3
Diabetes	22.6	11.6
Coronary Artery Disease	17.4	19.4	0.42
Systolic Blood Pressure	146.1 (22.8)	138.9 (19.5)	<.001
History of Stroke	5.1	5.0	0.96
Asprin use	35.8	37.7	0.53

ACE = angiotensin converting enzyme; 3MSE = Modified Mini Mental State Exam; CES-D = Center for Epidemiologic Studies- Depression Scale; LDL = serum low density lipoprotein, APOE-e4 = apolipoprotein E- epsilon 4 allele