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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Mar 2;1799(5-6):353–364. doi: 10.1016/j.bbagrm.2010.02.005

Fig. 7. O-GlcNAc modification regulates gluconeogenic gene expression in liver during diabetic conditions.

Fig. 7

Chronic hyperglycemia or diabetes causes induction of gluconeogenic gene expression by O-GlcNAc modification of the transcription factors CREB and FoxO-1 and their co-activators CRTC2 and PGC-1α, respectively. O-GlcNAc modification of CRTC2 under diabetic conditions causes CRTC2 translocation into the nucleus where it interacts with CREB to activate gluconeogenic gene expression. The co-activator PGC-1α has been demonstrated to be O-GlcNAc modified and to recruit OGT to FoxO-1, promoting O-GlcNAc modification of FoxO-1 and activation of gluconeogenic genes.