Table 3.
Cumulative 5- and 10-Year Risk of Developing CBC After a First Primary Invasive Breast Cancer According to Mutation Carrier Status and Age at Diagnosis of First Breast Cancer
| Age at First Breast Cancer (years) |
BRCA1 Mutation Carrier |
BRCA2 Mutation Carrier |
BRCA1 or BRCA2 Mutation Carrier |
Noncarriers |
||||
|---|---|---|---|---|---|---|---|---|
| Cumulative Risk (%) | 95% CI | Cumulative Risk (%) | 95% CI | Cumulative Risk (%) | 95% CI | Cumulative Risk (%) | 95% CI | |
| 5-Year risk for age group | ||||||||
| 25-29 | 16.0 | 8.5 to 30.1 | 14.6 | 6.5 to 32.9 | 15.5 | 8.8 to 27.4 | 3.2 | 2.3 to 4.4 |
| 30-34 | 17.0 | 9.5 to 30.5 | 15.5 | 7.1 to 33.7 | 16.5 | 9.9 to 27.6 | 3.4 | 2.8 to 4.2 |
| 35-39 | 13.2 | 7.4 to 23.5 | 12.0 | 5.6 to 26.0 | 12.8 | 7.7 to 21.3 | 2.6 | 2.2 to 3.1 |
| 40-44 | 9.8 | 5.5 to 17.4 | 8.9 | 4.1 to 19.3 | 9.5 | 5.8 to 15.8 | 1.9 | 1.6 to 2.3 |
| 45-49 | 7.3 | 2.7 to 19.7 | 6.5 | 2.9 to 14.4 | 6.7 | 3.6 to 12.6 | 2.8 | 2.6 to 3.1 |
| 50-54 | 6.0 | 2.2 to 16.3 | 5.3 | 2.4 to 11.9 | 5.6 | 2.9 to 10.3 | 2.3 | 2.1 to 2.6 |
| All ages combined (25-54) | 10.9 | 6.7 to 17.5 | 8.3 | 4.8 to 14.2 | 9.7 | 8.4 to 11.2 | 2.5 | 2.3 to 2.7 |
| 10-Year risk for age group | ||||||||
| 25-29 | 29.0 | 15.4 to 54.7 | 26.6 | 11.8 to 60.1 | 28.2 | 16.0 to 50.0 | 6.1 | 4.4 to 8.5 |
| 30-34 | 31.6 | 17.6 to 56.7 | 29.0 | 13.4 to 63.1 | 30.7 | 18.4 to 51.5 | 6.8 | 5.5 to 8.4 |
| 35-39 | 24.4 | 13.7 to 43.4 | 22.3 | 10.3 to 48.2 | 23.7 | 14.3 to 39.3 | 5.1 | 4.2 to 6.1 |
| 40-44 | 20.0 | 11.3 to 35.5 | 18.3 | 8.5 to 39.4 | 19.4 | 11.8 to 32.1 | 4.1 | 3.4 to 4.9 |
| 45-49 | 13.1 | 4.8 to 35.7 | 11.7 | 5.3 to 26.1 | 12.2 | 6.5 to 22.9 | 5.3 | 4.8 to 5.8 |
| 50-54 | 11.7 | 4.3 to 31.8 | 10.4 | 4.7 to 23.2 | 10.8 | 5.8 to 20.3 | 4.7 | 4.2 to 5.1 |
| All ages combined (25-54) | 20.5 | 12.7 to 33.0 | 15.9 | 9.2 to 27.2 | 18.4 | 16.0 to 21.3 | 4.9 | 4.5 to 5.4 |
NOTE. 5-Year and 10-year risks are calculated using the rate ratios for dichotomized age (< 45, ≥ 45).