Table 2.
Association Between Genotype and Overall Survival (N = 590)
| Gene and SNP | No. |
MST (months) | Log-Rank P | Cox Regression* |
||
|---|---|---|---|---|---|---|
| Patients | Deaths | HR | 95% CI | |||
| Risk SNPs | ||||||
| Unknown rs13099725 | ||||||
| AA | 434 | 402 | 23.31 | .007 | 1 | Reference |
| AG | 140 | 127 | 25.1 | 0.95 | 0.77 to 1.22 | |
| GG | 16 | 15 | 9.18 | 2.06 | 1.22 to 3.61 | |
| AA + AG | 574 | 529 | 23.84 | .002 | 1 | Reference |
| GG | 16 | 15 | 9.18 | 1.91 | 1.18 to 3.53 | |
| RGS22 rs4734443 | ||||||
| CC | 230 | 214 | 22.35 | .011 | 1 | Reference |
| TC | 269 | 244 | 25.93 | 0.92 | 0.74 to 1.20 | |
| TT | 91 | 86 | 16.39 | 1.36 | 1.07 to 1.76 | |
| TC + CC | 499 | 458 | 24.64 | .003 | 1 | Reference |
| TT | 91 | 86 | 16.39 | 1.33 | 1.01 to 1.82 | |
| BTBD2 rs11670188 | ||||||
| AA | 354 | 320 | 25.81 | .032 | 1 | Reference |
| AG | 198 | 188 | 19.77 | 1.29 | 1.03 to 1.58 | |
| GG | 38 | 36 | 20.52 | 1.33 | 0.94 to 1.81 | |
| AG + GG | 236 | 224 | 19.89 | .009 | 1.25 | 1.06 to 1.65 |
| LIG4 rs7325927 | ||||||
| CC | 309 | 282 | 25.26 | .058 | 1 | Reference |
| TC | 217 | 200 | 21.87 | 1.19 | 0.97 to 1.45 | |
| TT | 64 | 61 | 15.6 | 1.63 | 1.24 to 2.29 | |
| TC + TT | 281 | 261 | 16.81 | .008 | 1.54 | 1.06 to 2.12 |
| No. of risk alleles | ||||||
| 0-1 | 454 | 415 | 24.94 | .005 | 1 | Reference |
| 2-3 | 121 | 115 | 18.98 | 1.25 | 1.00 to 1.53 | |
| 4 | 15 | 14 | 9.86 | 1.69 | 1.01 to 2.95 | |
| Protective SNPs | ||||||
| RTEL1 rs2297440 | ||||||
| CC | 391 | 366 | 21.76 | .021 | 1 | Reference |
| TC | 179 | 162 | 25.82 | 0.83 | 0.60 to 1.02 | |
| TT | 19 | 15 | 27.95 | 0.55 | 0.26 to 0.94 | |
| TC + TT | 198 | 177 | 26.78 | .02 | 0.81 | 0.62 to 0.99 |
| RTEL1 rs6010620 | ||||||
| GG | 387 | 362 | 21.78 | .025 | 1 | Reference |
| AG | 183 | 166 | 25.71 | 0.81 | 0.63 to 1.04 | |
| AA | 20 | 16 | 27.1 | 0.57 | 0.27 to 0.95 | |
| AG + AA | 203 | 182 | 26.58 | .021 | 0.80 | 0.61 to 0.98 |
| No. of protective alleles | ||||||
| 0 | 387 | 362 | 21.77 | .023 | 1 | Reference |
| 1 | 182 | 165 | 25.78 | 0.84 | 0.71 to 1.02 | |
| 2 | 20 | 16 | 27.02 | 0.53 | 0.28 to 0.92 | |
| No. of at-risk alleles for the 6 SNPs† | ||||||
| 0-2 | 494 | 452 | 25.28 | < .001 | 1 | Reference |
| 3-4 | 83 | 80 | 14.37 | 1.75 | 1.25 to 2.19 | |
| 5-6 | 12 | 11 | 9.41 | 1.63 | 0.88 to 2.86 | |
Abbreviations: SNP, single nucleotide polymorphism; HR, hazard ratio. MST, median survival time (months).
*
Adjusted for diagnosis age, sex and extent of resection.
†
At-risk alleles were defined as the minor allele of the risk SNPs and the common allele of the protective SNPs.