Table 3.
Association Between the STS and LTS
| Gene and SNP | LTS (n = 97) |
STS (n = 202) |
P | Logistic Regression* |
|||
|---|---|---|---|---|---|---|---|
| No. | % | No. | % | OR | 95% CI | ||
| Risk SNPs | |||||||
| BTBD2 rs11670188 | |||||||
| AA | 69 | 71.1 | 117 | 57.9 | .067 | 1 | Reference |
| AG | 23 | 23.7 | 71 | 35.1 | 2.12 | 1.09 to 4.35 | |
| GG | 5 | 5.2 | 14 | 6.9 | 1.79 | 0.43 to 5.26 | |
| AG + GG | 28 | 28.9 | 85 | 42.1 | .02 | 2.03 | 1.09 to 3.81 |
| LIG4 rs7325927 | |||||||
| CC | 62 | 64.6 | 104 | 51.5 | .001 | 1 | Reference |
| TC | 28 | 29.2 | 72 | 35.6 | 2.33 | 1.13 to 4.55 | |
| TT | 6 | 6.2 | 26 | 12.9 | 3.70 | 1.09 to 11.11 | |
| TC + TT | 34 | 35.4 | 98 | 48.5 | .004 | 2.45 | 1.32 to 4.56 |
| No. of risk alleles | |||||||
| 0 | 43 | 44.8 | 62 | 30.7 | .046 | 1 | Reference |
| 1 | 49 | 51.0 | 129 | 63.9 | 1.92 | 1.12 to 3.23 | |
| 2 | 4 | 4.2 | 11 | 4.4 | 2.78 | 0.66 to 9.89 | |
| Protective SNPs | |||||||
| RTEL1 rs2297440 | |||||||
| CC | 57 | 58.8 | 142 | 70.3 | .048 | 1 | Reference |
| TC | 36 | 37.1 | 58 | 28.7 | 0.52 | 0.28 to 0.97 | |
| TT | 4 | 4.1 | 2 | 1.0 | 0.16 | 0.02 to 1.37 | |
| TC + TT | 40 | 41.2 | 60 | 29.7 | .027 | 0.50 | 0.27 to 0.93 |
| RTEL1 rs6010620 | |||||||
| GG | 57 | 58.8 | 141 | 69.8 | .082 | 1 | Reference |
| AG | 36 | 37.1 | 58 | 28.7 | 0.53 | 0.28 to 0.97 | |
| AA | 4 | 4.1 | 3 | 1.5 | 0.41 | 0.06 to 2.86 | |
| AG + AA | 40 | 41.2 | 61 | 30.2 | .041 | 0.53 | 0.29 to 0.98 |
| HMGA2 rs1563834 | |||||||
| GG | 63 | 66 | 153 | 75.7 | .021 | 1 | Reference |
| AG | 29 | 27.8 | 48 | 23.8 | 0.63 | 0.32 to 1.20 | |
| AA | 4 | 4.1 | 1 | 0.5 | 0.06 | 0.01 to 0.78 | |
| AG + AA | 33 | 34 | 49 | 24.3 | .045 | 0.56 | 0.27 to 0.99 |
| CCDC26 rs10464870 | |||||||
| TT | 49 | 50.5 | 133 | 65.8 | < .001 | 1 | Reference |
| TC | 38 | 39.2 | 66 | 32.7 | 0.62 | 0.38 to 1.01 | |
| CC | 10 | 10.3 | 3 | 1.5 | 0.11 | 0.04 to 0.49 | |
| TC + CC | 48 | 49.5 | 69 | 34.2 | .016 | 0.53 | 0.30 to 0.89 |
| CCDC26 rs891835 | |||||||
| TT | 48 | 49.5 | 128 | 63.4 | .01 | 1 | Reference |
| TG | 41 | 42.3 | 70 | 34.6 | 0.56 | 0.30 to 1.01 | |
| GG | 8 | 8.2 | 4 | 2.0 | 0.19 | 0.05 to 0.65 | |
| TG + GG | 49 | 50.5 | 74 | 36.6 | .026 | 0.51 | 0.28 to 0.93 |
| VPS8 rs6765837 | |||||||
| TT | 18 | 18.6 | 64 | 31.7 | .056 | 1 | Reference |
| TC | 58 | 59.8 | 97 | 48 | 0.46 | 0.23 to 0.91 | |
| CC | 21 | 21.6 | 41 | 20.3 | 0.54 | 0.24 to 1.22 | |
| TC + CC | 79 | 81.4 | 138 | 68.3 | .028 | 0.49 | 0.26 to 0.92 |
| No. of protective alleles | |||||||
| 0-1 | 8 | 8.2 | 53 | 26.2 | < .001 | 1 | Reference |
| 2-3 | 70 | 72.2 | 126 | 62.4 | 0.26 | 0.12 to 0.61 | |
| 4-6 | 19 | 19.6 | 23 | 11.4 | 0.17 | 0.08 to 0.54 | |
| No. of at-risk alleles for the 8 SNPs† | |||||||
| 0-2 | 8 | 8.2 | 56 | 27.7 | < .001 | 1 | Reference |
| 3-4 | 62 | 63.9 | 124 | 61.4 | 3.57 | 1.54 to 8.43 | |
| 5-8 | 27 | 27.8 | 22 | 10.9 | 8.53 | 3.23 to 22.98 | |
Abbreviations: STS, short-term survivors; LTS, long-term survivors; SNP, single nucleotide polymorphism; OR, odds ratio.
*
Adjusted for age, sex, and extent of resection.
†
At-risk alleles were defined as the minor allele of the risk SNPs and the common allele of the protective SNPs.