Table A3.

Association Between Genotype and Overall Survival in UCSF and Sweden Replication Groups

Gene and SNP	UCSF (N = 352)					Sweden (N = 191)
	No. of Patients	No. of Deaths	MST (months)	HR	95% CI	No. of Patients	No. of Deaths	MST (months)	HR	95% CI
LIG4 rs7325927
CC	182	161	15.7	1	Reference	105	92	12.5	1	Reference
TC	153	127	18.1	0.86	0.68 to 1.09	65	55	15.6	0.69	0.49 to 1.01
TT	17	12	15	0.79	0.44 to 1.44	6	5	10.4	1.57	0.57 to 4.36
TC + TT	170	139	17.8	0.86	0.68 to 1.08	71	60	14.8	0.72	0.51 to 1.04
BTBD2 rs11670188
AA	212	178	17.8	1	Reference	NA
AG	113	101	14.5	1.31	1.03 to 1.68
GG	27	21	20	0.83	0.53 to 1.30
AG + GG	140	122	15.6	1.19	0.95 to 1.50
CCDC26 rs10464870
TT	225	194	16.3	1	Reference	105	94	13.4	1	Reference
TC	111	93	17.1	1.05	0.82 to 1.35	55	44	14.7	0.95	0.64 to 1.40
CC	16	13	16.9	1.19	0.68 to 2.09	15	13	13.6	0.95	0.51 to 1.80
TC + CC	127	106	17.1	1.06	0.84 to 1.35	70	57	14.3	0.95	0.66 to 1.36
CCDC26 rs891835
TT	210	178	17.8	1	Reference	103	93	12.9	1	Reference
TG	123	107	14.8	1.31	0.99 to 1.67	59	48	14.7	0.95	0.66 to 1.39
GG	19	15	18.1	1.10	0.65 to 1.87	16	13	14.6	0.78	0.41 to 1.47
TG + GG	142	122	14.9	1.29	0.98 to 1.63	75	61	14.6	0.91	0.64 to 1.29
RTEL1 rs2297440
CC	251	216	15.9	1	Reference	114	100	13.1	1	Reference
TC	95	79	18.6	1.05	0.81 to 1.37	57	48	15.2	1.11	0.77 to 1.61
TT	4	3	19.4	0.73	0.23 to 2.29	6	5	11.9	1.39	0.55 to 3.51
TC + TT	99	82	18.6	1.03	0.8 to 1.34	63	53	14.5	1.14	0.80 to 1.62

Abbreviations: UCSF, University of California San Francisco; MST, median survival time; HR, hazard ratio; NA, not available.

^*Adjusted for age and sex.