Table 5.

Radiotherapy (based on radiotherapy planning data submitted to ITC) and Esophagitis and Lung Toxicity at Any Time With Heterogeneity Corrections (n = 53)

Radiotherapy	Grade < 3 Lung Toxicity (n = 39)		Grade ≥ 3 Lung Toxicity (n = 12)		P	Grade < 2 Esophagitis (n = 30)		Grade ≥ 2 Esophagitis (n = 21)		P
	No.	%	No.	%		No.	%	No.	%
Lung V20
Median	24.1		26.3		.62*	22.4		26.3		.22*
Range	9.9-35.7		15.6-33.3			9.9-35.7		14.0-33.3
< 25%	13	33	5	42	.73†
≥ 25%	27	68	7	58
≤ 30%	34	85	12	100	.32†
> 30%	6	15	0	0
Mean lung dose, Gy
Median	15.2		17.2		.30‡	14.5		16.9		.17‡
Range	5.7-21.8		11.5-18.9			5.7-21.8		9.9-20.6
≤ 20	37	95	12	100	1.00†
> 20	2	5	0	0
Mean esophageal dose, Gy (n = 22)
Median						21.0		24.6		.08‡
Range						7.1-34.9		16.2-33.7
≤ 30						27	90	19	86	.69†
> 30						3	10	3	14

Abbreviations: ITC, Image-Guided Therapy Center; V20, volume of lung at or exceeding 20 Gy.

^*Wilcoxon rank sum test.

^†t test.

^‡Fisher's exact test.