Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
hIAPP, mIAPP, and insulin mRNA levels in hIAPP transgenic islets following 144-h culture
Neprilysin was inhibited by co-culture of islets with the neprilysin inhibitor thiorphan, or up-regulated by infection with a neprilysin-containing adenovirus (AdV-NEP). Levels are expressed relative to that in control islets (n = 5/group).
| Control | Inhibitor | AdV-NEP | |
|---|---|---|---|
| hIAPP mRNA | 1.00 | 0.64 ± 0.16 | 1.15 ± 0.12 |
| mIAPP mRNA | 1.00 | 0.99 ± 0.17 | 1.16 ± 0.15 |
| Insulin mRNA | 1.00 | 0.91 ± 0.09 | 1.34 ± 0.23 |
