TABLE 3.
Structural environments of two-stranded β-sheets with the highest strand separations
aa, amino acid.
| PDB codea | Strands (length (aa))b | Separationc | Environment |
Single module?e | Intervening motiff | |
|---|---|---|---|---|---|---|
| Strand 1d | Strand 2d | |||||
| 1HHS(A) | 143(4) 646(4) | 499 | X | CT | No | Multiple |
| 2BMO(A) | 13(3) 380(3) | 364 | NT | M | No | Multiple |
| 1K32(A) | 291(4) 652(4) | 357 | Cap | Cap | Yes | β-Propeller |
| 2BJK(A) | 165(9) 507(9) | 333 | M | CT | No | Multiple |
| 1WTJ(B) | 10(4) 327(4) | 313 | NT | CT | No | Multiple |
| 1Y7B(A) | 3(3) 313(3) | 307 | NT | Cap | Yes | β-Propeller |
| 1DMR | 183(3) 438(3) | 252 | Cap | X | Yes* | α/β |
| 1EDT | 28(3) 267(3) | 236 | M | CT | Yes | β-Barrel |
| 2BUM(B) | 5(5) 231(4) | 221 | NT | CT | Yes | β-Ensemble |
| 2GQT(A) | 51(3) 265(3) | 211 | M | CT | No | Multiple |
| 1C1K(A) | 2(3) 197(3) | 192 | NT | CT | No | Multiple |
| 1X7Y(B) | 18(4) 199(4) | 177 | NT | Cap | Yes | α/β |
| 1V5E(A) | 3(3) 169(3) | 163 | NT | Cap | Yes | α/β |
| 2B3Y(A) | 74(4) 234(4) | 156 | Cap | Cap | Yes | α/β |
| 2FA1(B) | 9(4) 154(4) | 141 | NT | CT | Yes | β-Ensemble |
| 1G8L(A) | 27(5) 171(5) | 139 | NT | Cap | Yes | ↑↓-Coil |
| 1GNL(A) | 223(4) 364(4) | 137 | Cap | Cap | Yes | α/β |
| 1GV4(A) | 179(3) 317(3) | 135 | Cap | Cap | Yes | α/β |
| 1ESG(B) | 46(3) 183(3) | 134 | M | M | Yes | α/β |
| 1Q1R(A) | 112(3) 248(3) | 133 | Cap | Cap | Yes | α/β |
| 1FN9(A) | 221(3) 356(3) | 132 | M | CT | No | Multiple |
| 1T1E | 14(3) 147(3) | 130 | NT | M | Yes | ↑↓ |
| 3GRS | 158(3) 291(3) | 130 | Cap | Cap | Yes | α/β |
| 1JR2(B) | 57(5) 189(5) | 127 | Cap | Cap | Yes | α/β |
| 2GAG(A) | 251(3) 381(3) | 127 | Cap | Cap | Yes | α/β |
| 2C65(B) | 79(3) 208(3) | 126 | Cap | Cap | Yes | α-Ensemble |
| 1HYU(A) | 324(3) 451(3) | 124 | Cap | Cap | Yes | α/β |
| 1YQZ(A) | 115(3) 239(3) | 121 | Cap | Cap | Yes | α/β |
| 1WCW(A) | 39(5) 163(5) | 119 | Cap | Cap | Yes | α/β |
| 1ZK7(A) | 148(3) 269(3) | 118 | Cap | Cap | Yes | α/β |
| 2CVE(A) | 3(3) 121(3) | 115 | NT | Cap | Yes | α/β |
| 1W4X(A) | 222(3) 339(3) | 114 | X | M | Yes | α-Ensemble |
| 1O7E(B) | 51(3) 166(3) | 112 | Cap | M | Yes | α-Ensemble |
| 1FZW(C) | 111(4) 222(4) | 107 | M | M | Yes | α/β |
| 2DQ6(A) | 308(3) 414(3) | 103 | M | M | Yes | α-Ensemble |
a The PDB code is followed by the chain ID (in parentheses).
b The first residue for each strand is listed followed by the length of each strand (in parentheses).
c Number of intervening residues between the strands in the two-stranded β-sheet.
d Environments: NT, chain N-terminal region; CT, chain C-terminal region; M, module interior; Cap, module cap, just beyond a structural module; X, extended coil region.
e Indicates whether the strands and the intervening residues are part of s single, compact structural module. Yes*, Yes, with additional extended topology to join the module entry/exit points.
f Motifs adopted by interstrand residues. Introduced nomenclature: ↑↓, antiparallel architecture, culminating in a β-hairpin turn; ↑↓, coil: mostly coil antiparallel architecture.