FIGURE 8.

GSH-EE therapy restores mitochondrial GSH and protects against MCD- and MD-induced hepatocellular damage. A, scheme outlines the treatment of MCD and MD-fed mice with GSH-EE. GSH-EE was administered intraperitoneally 1 week after mice were fed a MCD or MD diet and maintained for another week given twice a day. B, liver samples were processed and fractionated to isolate mitochondria to determine GSH levels. C, ALT release in serum was determined from the different groups of mice with or without GSH-EE administration. Results are the mean ± S.D. of four to six individual mice. *, p < 0.05 versus control mice.