FIGURE 5.

Comparison of x-ray crystallographic structures of the Eg5 motor domain bound with L5-directed inhibitors shows distortions in β-sheets. Shown is a region of the antiparallel β-sheet of the Eg5 motor domain; other structural motifs that cover the central β-sheet were removed in PyMOL for visual clarity. The wild type Eg5·ADP structure (PDB ID 1II6) in gray is overlaid on the ternary structure in complex with STC (PDB ID 3KEN) in green (A), monastrol (PDB ID 1X88) in blue (B), and a tetrahydroisoquinoline carboxamide in pink (PDB ID 2FME) (C). Appropriate β-strands are labeled.