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. Author manuscript; available in PMC: 2010 Jun 7.
Published in final edited form as: Drug Metab Dispos. 2007 Dec 20;36(3):490–499. doi: 10.1124/dmd.107.016501

FIG. 3.

FIG. 3

Kinetic profiles of testosterone 6β-hydroxylase activity of purified functionally reconstituted CYP3A4(His)6 before or after CBZ-modification. A, kinetic profile with enzyme preincubation in the absence of both CBZ and NADPH. B, kinetic profile with enzyme preincubation with CBZ in the absence of NADPH. C, kinetic profile with enzyme preincubation with CBZ and NADPH. Data shown are the average mean ± S.D. of three independent experiments.