Table 2.
Association of Lung Cancer Risk With Circulating CRP Levels and CRP Genotypes
| CRP Level and Genotype | Controls* |
Patients* |
OR | 95% CI† | P-Trend | Adjusted OR | 95% CI‡ | P-Trend | ||
|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | |||||||
| CRP, mg/L | < .001 | < .001 | ||||||||
| ≤ 1.0 | 168 | 25.1 | 106 | 17.9 | 1.00 | 1.00 | ||||
| 1.1-2.7 | 176 | 26.3 | 136 | 23.0 | 1.26 | 0.88 to 1.80 | 1.22 | 0.83 to 1.78 | ||
| 2.8-5.5 | 167 | 24.9 | 150 | 25.3 | 1.41 | 1.00 to 1.98 | 1.54 | 1.08 to 2.21 | ||
| ≥ 5.6 | 159 | 23.7 | 200 | 33.8 | 1.95 | 1.38 to 2.75 | 1.98 | 1.35 to 2.89 | ||
| rs1417938 | .952 | .880 | ||||||||
| AA | 221 | 49.4 | 186 | 49.2 | 1.00 | 1.00 | ||||
| AT | 177 | 39.6 | 149 | 39.4 | 1.00 | 0.74 to 1.34 | 1.04 | 0.76 to 1.42 | ||
| TT | 49 | 11.0 | 42 | 11.1 | 1.01 | 0.64 to 1.60 | 1.00 | 0.62 to 1.63 | ||
| rs1800947 | .677 | .456 | ||||||||
| GG | 399 | 89.3 | 335 | 88.6 | 1.00 | 1.00 | ||||
| CG | 46 | 10.3 | 40 | 10.6 | 1.03 | 0.66 to 1.62 | 1.16 | 0.72 to 1.88 | ||
| CC | 2 | 0.4 | 3 | 0.8 | 1.78 | 0.29 to 10.73 | 1.50 | 0.22 to 9.94 | ||
| rs1205 | .960 | .667 | ||||||||
| CC | 204 | 45.7 | 167 | 44.2 | 1.00 | 1.00 | ||||
| CT | 188 | 42.2 | 168 | 44.8 | 1.09 | 0.81 to 1.46 | 1.12 | 0.82 to 1.54 | ||
| TT | 54 | 12.1 | 40 | 10.7 | 0.90 | 0.57 to 1.42 | 1.02 | 0.63 to 1.67 | ||
| rs2808630 | .527 | .652 | ||||||||
| TT | 242 | 54.1 | 206 | 54.5 | 1.00 | 1.00 | ||||
| CT | 172 | 38.5 | 153 | 40.5 | 1.04 | 0.78 to 1.39 | 1.05 | 0.77 to 1.41 | ||
| CC | 33 | 7.4 | 19 | 5.0 | 0.67 | 0.37 to 1.22 | 0.72 | 0.38 to 1.34 | ||
| rs3093077 | .813 | .570 | ||||||||
| TT | 375 | 83.9 | 316 | 83.6 | 1.00 | 1.00 | ||||
| GT | 70 | 15.7 | 59 | 15.6 | 1.00 | 0.68 to 1.45 | 0.87 | 0.57 to 1.31 | ||
| GG | 2 | 0.4 | 3 | 0.8 | 1.77 | 0.29 to 10.69 | 1.07 | 0.16 to 7.14 | ||
NOTE. Values in boldface are statistically significant at P < .05. Numbers do not add up to total owing to missing values.
Abbreviations: CRP, C-reactive protein; OR, odds ratio.
Analyses for circulating CRP levels included 592 patients and 670 controls. Analyses for CRP genotypes included 378 patients and 447 controls.
ORs were calculated using conditional logistic regression (CRP levels) or unconditional logistic regression (CRP single nucleotide polymorphisms [SNPs]). ORs for CRP levels were adjusted for matching factors: age at enrollment, sex, year of random assignment, follow-up time in study, and smoking status. ORs for CRP SNPs were not adjusted for any factors.
Adjusted ORs included adjustment for matching factors (CRP/SNP associations adjusted for age, sex, and smoking status) and additionally for race, level of education, body mass index at enrollment, regular use of aspirin/ibuprofen, family history of lung cancer, history of heart disease, and history of emphysema/bronchitis.