Table 1.

CYP2D6 Allele Frequencies in Different Ethnic Populations

Location of Population	Functional			Nonfunctional				Reduced					Duplications					New†
	*1	*2	*39	*3	*4	*5	*6	*9	*10	*17	*29	*41	*1 × N	*2 × N	*4 × N	*10 × N	*41 × N
Sub-Saharan Africa	24.4	32.7	—	—	2.8	5.9	—	—	4.3	12.2	6.7	2.8	2.4	0.8	3.5	—	—	1.6
North Africa	11.7	28.3	—	—	11.7	3.3	—	—	—	8.3	—	8.3	—	28.3	—	—	—	—
Middle East	35.1	25.0	—	—	6.8	3.7	1.4	—	0.7	2.0	—	16.9	3.7	3.4	—	—	—	1.4
Europe	34.4	28.7	—	0.3	17.2	3.2	0.6	2.5	2.9	—	—	7.0	0.6	1.3	0.6	0.3	—	0.3
Central/South Asia	43.3	29.0	0.2	—	8.1	3.8	—	—	3.8	—	0.2	10.5	0.5	0.5	—	—	—	—
East Asia	30.9	16.4	0.2	—	2.7	5.8	—	—	39.4	—	—	2.3	0.4	0.6	—	1.0	0.2	—
Oceania	70.1	—	—	—	—	1.3	—	—	2.6	—	—	—	11.5	—	—	—	—	12.8
America	60.2	30.1	—	—	3.2	0.9	—	—	—	0.5	—	—	2.3	2.8	—	—	—	—

NOTE. A total of 1,060 individuals belonging to 52 populations across the globe were genotyped at 12 variable sites, as well as for gene deletion and duplications. Data modified with permission.²⁹

^*Variant allele.

^†New haplotypes identified by Sistonen et al.²⁹