Figure 2. Electrophysiological properties of four group 1 mutant channels expressed by HEK293 cells.

Individual parameters are summarized in Table 1. (A) Peak current-to-voltage (I–V) relationships. Currents were elicited from the holding potential of −120 mV to the test potentials indicated. (B) Steady-state activation as a function of voltage. (C) Steady-state inactivation as a function of voltage. (D) Recovery from inactivation. Normalized data were fitted to double exponentials yielding the fast and slow time constants listed in Table 1. (E, F) Time constant of inactivation (τ_h) as a function of voltage. Parameters were obtained from monoexponential fits. Error bars represent the mean ± SEM.