Figure 7. Model for vaccine-induced stem-like properties in gliomas.

Model accounting for qualitatively and quantitatively distinct enrichment of glioma CSCs by endogenous T cells, chemotherapy and vaccination. The model takes distinct synergy of endogenous and vaccine-mediated T cell activity with chemotherapy, and therapy-mediated marker dynamics into account. In the absence of any T cells, substantial numbers of Egfr⁺ tumor cells are expected to persist, whereas T cells down-regulate Egfr and proportionally up-regulate Shh expression.