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. Author manuscript; available in PMC: 2011 May 5.
Published in final edited form as: Cell Metab. 2010 Apr 22;11(5):427–437. doi: 10.1016/j.cmet.2010.04.002

Figure 6. SH2B regulates longevity differently between flies and mice.

Figure 6

(A–B) Survival curves of wild type (WT) and dSH2B deficient flies (200 flies per group). (C–D) Survival curves of actin-GAL4/+ (act-Con) or actin-GAL4/UAS-dSH2B (act-dSH2B) flies (140 flies per group). (E–F) Survival curves of elav-GAL4/+ (elav-Con) or elav- GAL/UAS-dSH2B (elav-dSH2B) flies (180 flies per group). (G) Blood glucose levels in fed (44 weeks; WT: n=12, KO: n=10) and fasted (49 weeks; WT: n=12, KO: n=9) females. (H) WT (n=16) and KO (n=18) females were housed in a pathogen-free room, and their survivals were monitored daily. Survival rates were calculated as % of the initial number of mice. *p<0.05.

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