Figure 1.

Molecular interaction network of fludarabine-regulated genes in cells of sensitive CLL patients in vivo. A group of genes highly regulated by fludarabine in sensitive patients (following a 24h exposure in vivo) was clustered in a network around the transcription regulators TP53 and MYC using the Ingenuity Pathway Analysis software (IPA 8.0, database Nov 2009). A, Gene expression values obtained from sensitive patients were overlaid on the network. B. Gene expression values obtained from resistant patients were overlaid on the network.