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. 2010 May 20;9:115. doi: 10.1186/1476-4598-9-115

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Copyright ©2010 Moussay et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Molecular interaction network of fludarabine-regulated genes in cells of resistant CLL patients in vivo. A group of genes highly regulated by fludarabine in resistant patients (following a 24h exposure in vivo) was clustered in a network around the transcription regulators TP53 and MYC using the Ingenuity Pathway Analysis software (IPA 8.0, database Nov 2009). A. Gene expression values obtained from resistant patients were overlaid on the network. B. Gene expression values obtained from sensitive patients were overlaid on the network.