Table 2.

Gene set enrichment analysis (GSEA) of CLL B cells from fludarabine-sensitive and -resistant patients

Function/Pathway	Gene sets enriched in sensitive patients	Size	NES	NOM p-val
p53 response	STRESS_ARSENIC_SPECIFIC_UP	6	1.76	0.002
	P53PATHWAY	6	1.61	0.004
	HSA04115_P53_SIGNALING_PATHWAY	13	1.62	0.006
	P53GENES_ALL	9	1.53	0.021
	P53_BRCA1_UP	5	1.50	0.030
	STRESS_P53_SPECIFIC_UP	5	1.44	0.031
	KANNAN_P53_UP	9	1.51	0.032
DNA damage response	DNA_DAMAGE_SIGNALING	13	1.69	0.008
	UVC_TTD-XPCS_COMMON_DN	8	1.69	0.014
	CIS_XPC_DN	10	1.73	0.017
DNA repair, cell cycle, apoptosis	BLEO_HUMAN_LYMPH_HIGH_4HRS_UP	9	1.59	0.028
BAFF/APRIL receptor	MOREAUX_TACI_HI_VS_LOW_UP	8	1.45	0.023
hTERT-regulated genes	SMITH_HTERT_DN	5	1.57	0.028
	ROTH_HTERT_DIFF	7	1.48	0.049
NF-KB signaling	HINATA_NFKB_UP	6	1.53	0.032
Cell death	APOPTOSIS	6	1.55	0.034
	BRENTANI_DEATH	6	1.55	0.034
	APOPTOSIS_GENMAPP	5	1.56	0.035
Cell cycle	CELL_CYCLE_KEGG	6	1.52	0.044
	CELL_CYCLE	6	1.52	0.044
	TAKEDA_NUP8_HOXA9_16D_DN	11	1.43	0.045
Function/Pathway	Gene sets enriched in resistant patients	Size	NES	NOM p-val
T lymphocyte proliferation	GOLDRATH_HP	14	1.61	0.008
EGR2-regulated genes	LE_MYELIN_UP	6	1.58	0.009
Genes involved in cholera infection	HSA05110_CHOLERA_INFECTION	5	1.63	0.023
Myeloma cell growth and survival	CHAUHAN_2ME2	5	1.50	0.042
DNA and RNA metabolism	WERNER_FIBRO_DN	5	1.45	0.059
p53 response, anti-apoptosis, DNA repair	UVB_SCC_DN	6	1.39	0.086
Myc-regulated genes	MYC_ONCOGENIC_SIGNATURE	8	1.37	0.061
Functions of mature T lymphocytes	LEE_TCELLS2_UP	46	1.27	0.084
Hematopoeitic stem cell genes	BYSTRYKH_HSC_TRANS_GLOCUS	29	1.38	0.070
APC-regulated genes	SANSOM_APC_LOSS5_UP	10	1.47	0.084

NES Normalized Enrichment Score, NOM p-val Nominal p-value