Table 3.
Effects of β2-agonist isomers on Mycoplasma pneumoniae (Mp) load in cultured human airway epithelial cells*
| Normal subjects | Asthma | COPD | ||||
|---|---|---|---|---|---|---|
| Mp | Mp + CSE† | Mp | Mp + CSE | Mp | Mp + CSE | |
| (R)-albuterol | 0.03 | 0.16 | 0.03 | 0.24 | 0.43 | 0.14 |
| Racemic albuterol | 0.14 | 0.09 | 0.08 | 0.10 | 0.08 | 0.16 |
| (S)-albuterol | 0.01 | 0.48 | 0.15 | 0.21 | 0.44 | 0.20 |
| (R,R)-formoterol | 0.17 | 0.03 | 0.04 | 0.10 | 0.07 | 0.15 |
| Racemic formoterol | 0.48 | 0.10 | 0.01 | 0.37 | 0.13 | 0.08 |
| (S,S)-formoterol | 0.01 | 0.25 | 0.77 | 0.55 | 0.64 | 0.24 |
*, Data are presented as p values. A p value ≤ 0.05 is considered statistically significant. The p values were obtained by comparing β2-agonists with no drug treatments. †, CSE = cigarette smoke extract.