Table 1.
Characteristics of the Sample by Family History of a Cancer Associated with an Inherited Syndromea
| None | 1 Relative or subject (age ≥50) | 1 Relative or subject (age <50) | ≥2 (including subject) | p-value | |
|---|---|---|---|---|---|
| Sample N | 26,341 | 2,448 | 1,721 | 918 | |
| Weighted N | 183,923,404 | 16,464,723 | 11,573,968 | 5,811,660 | |
| % | % | % | % | ||
| Overall | 84.5 | 7.6 | 5.3 | 2.7 | |
| Sex | <0.0001 | ||||
| Male | 49.9 | 43.2 | 37.9 | 27.7 | |
| Female | 50.1 | 56.8 | 62.1 | 72.3 | |
| Age (years) | <0.0001 | ||||
| 18–39 | 44.5 | 12.3 | 31.0 | 8.9 | |
| 40–49 | 20.5 | 20.2 | 23.7 | 14.0 | |
| 50–59 | 16.1 | 23.1 | 19.0 | 22.7 | |
| 60–69 | 9.3 | 20.8 | 13.0 | 21.8 | |
| ≥70 | 9.7 | 23.7 | 13.2 | 32.6 | |
| Race/ethnicity | <0.0001 | ||||
| Hispanic | 13.9 | 6.2 | 8.5 | 4.4 | |
| African-American, Other non-Hispanic | 16.9 | 9.7 | 12.5 | 9.7 | |
| White, non-Hispanic | 69.3 | 84.1 | 78.9 | 85.9 | |
| Educationb | <0.0001 | ||||
| <High school graduate | 16.7 | 11.9 | 15.7 | 15.4 | |
| High school graduate | 29.5 | 29.0 | 30.7 | 34.8 | |
| Some college | 28.3 | 28.4 | 28.5 | 28.0 | |
| College graduate | 25.5 | 30.7 | 25.1 | 21.8 | |
| Marital Statusb | <0.0001 | ||||
| Married/ living with partner | 62.6 | 68.0 | 65.0 | 62.4 | |
| Not married | 37.4 | 32.0 | 35.0 | 37.6 | |
| Body mass indexb | <0.0001 | ||||
| Underweight/normal | 40.8 | 33.3 | 36.2 | 32.5 | |
| Overweight | 34.9 | 40.1 | 34.3 | 37.9 | |
| Obese | 24.3 | 26.5 | 29.5 | 29.6 | |
| Number of comorbid conditions | <0.0001 | ||||
| None | 50.0 | 29.1 | 35.0 | 20.5 | |
| 1 | 26.9 | 32.0 | 29.8 | 29.8 | |
| 2 | 14.1 | 21.2 | 19.8 | 25.1 | |
| ≥3 | 8.9 | 17.3 | 15.4 | 24.6 | |
| Personal history of cancer | <0.0001 | ||||
| No cancer | 96.4 | 81.0 | 84.2 | 65.4 | |
| BRCA-/Lynch-associated cancera | 0 | 12.2 | 11.3 | 28.3 | |
| Other cancer | 3.6 | 6.8 | 4.5 | 6.3 | |
| Current smokerb | <0.0001 | ||||
| Yes | 21.5 | 15.8 | 22.9 | 14.2 | |
| No | 78.5 | 84.2 | 77.1 | 85.8 | |
| Self-perceived poor healthb | <0.0001 | ||||
| Yes | 11.3 | 16.2 | 17.9 | 23.5 | |
| No | 88.7 | 83.8 | 82.1 | 76.5 | |
| Born in USb | <0.0001 | ||||
| Yes | 82.9 | 91.9 | 91.3 | 94.4 | |
| No | 17.1 | 8.1 | 8.7 | 5.6 | |
| Region of US | 0.0001 | ||||
| Northeast | 18.2 | 19.9 | 16.2 | 20.8 | |
| Midwest | 24.3 | 27.5 | 26.2 | 27.6 | |
| West | 21.0 | 19.0 | 19.1 | 21.1 | |
| South | 36.5 | 33.6 | 38.4 | 30.5 |
Percentages are weighted. P-values are from chi-square tests. aCancers included: breast, ovarian (BRCA), colorectal, uterine (Lynch)
bMissing: education, 355; marital status, 165; body mass index, 1,430; current smoker, 277; self-perceived poor health, 15; born in US, 27