Fig. 6A–E.

At 45 days, no tissue formation was present in the (A) rhBMP-2/CPC composite, but bone ingrowth was observed in the (B) rhBMP-2/GM/CPC composite. At 140 days, still no bone ingrowth was observed in the (C) rhBMP-2/CPC composite, but more bone ingrowth and faster degradation were observed in the (D) rhBMP-2/GM/CPC composite. A large bone defect was still present in the vertebra of the (E) untreated group at 140 days. (Stain, modified Ponceau trichrome; original magnification, ×16).