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Pharmacological selectivity of AF-792
| Receptor | n | pIC50 ± SEM |
|---|---|---|
| Rat P2X3 | 13 | 8.20 ± 0.06 |
| Human P2X2/3 | 15 | 7.94 ± 0.08 |
| Human P2X1 | 3 | <5 |
| Human P2X2 | 3 | <5 |
| Human P2X4 | 3 | <5 |
| Rat P2X5 | 3 | <5 |
| Human P2X7 | 3 | <5 |
pIC50 values for all of the P2X channels were obtained from αβmeATP or ATP-evoked intracellular calcium flux in recombinant cell lines in the presence of AF-792.
