Table 2. Multiple roles for junctional proteins.

Table summarising recent data demonstrating the specific roles that EC junctional proteins have in relation to leukocyte sub-types, inflammatory stimuli, and the stage and type of transmigration. This is an updated and expanded version of a previously published table [42]

EC junctional molecules exhibiting specific roles	Details of transmigration response
Leukocyte sub-type specificity
PECAM-1	TEM of monocytes, PMN and NK cells but only some sub-sets of lymphocytes.	42
ESAM	Transmigration of PMN but not lymphocytes.	43
CD99L2	Transmigration of PMN but not lymphocytes.	44
Stimulus specificity
PECAM-1	Transmigration induced by IL-1β, L-Name, and H2O2, but not TNFα, HCl, adenovirus, IL-8 or LTB4.	42
JAM-A	Responses induced by IL-1β, I/R and cytokine stimulated meningitis, but not bacterial or virally stimulated meningitis, LTB4 or PAF stimulated responses.	28, 42
ICAM-2	Transmigration induced by IL-1β but not TNFα or thioglycollate.	45**, 46
Stage of migration
ICAM-2	Entry to the EC junction.	45
PECAM-1	Leukocyte migration through the endothelium and the EC basement membrane.	28, 42, 45**
JAM-A	Migration through EC junction.	28
CD99	Migration through ECs at a stage distal to and subsequent to that mediated by PECAM-1.	47, 48
CD99L2	Leukocyte migration through the basement membrane.	44
Transcellular migration
JAM-A	Associated with transcellular pores.	17
PECAM-1	Associated with transcellular pores, and contributes to transcellular migration.	17
Reverse transmigration
JAM-C	Regulates unidirectional monocyte TEM.	49

Adapted with permission from reference [42]