Table 2. Survival comparisons by best RECIST response (1st phase I trial).
Response | N | Deaths | Median OS in months (95%CI) | (%) Survival at 1 Year (95%CI) | P-value |
---|---|---|---|---|---|
All patients | 85 | 58 | 7.9 (6.1 - 10.1) | 0.29 (0.21 - 0.44) | |
CR/PR/SD vs. | 25 | 10 | 14.9 (10.1 - NA) | 0.51 (0.33 - 0.82) | <0.0001 |
PD/Not evaluable | 60 | 48 | 6.01 (4.5 - 7.9) | 0.21 (0.12 - 0.37) | |
PD/Not evaluable vs. | 60 | 48 | 6.01 (4.5 - 7.9) | 0.21 (0.12 - 0.37) | 0.004 |
SD | 19 | 9 | 11.0 (8.9 - NA) | 0.42 (0.22 - 0.81) |
Abbreviations: OS = overall survival, CI = confidence interval, CR = complete response, PR = partial response, SD = stable disease, PD = progressive disease, NA = not available (insufficient events/deaths to define an upper boundary)