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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Clin Lab Med. 2010 Mar;30(1):261–292. doi: 10.1016/j.cll.2009.10.004

Figure 11.

Figure 11

A) Hepatic histopathology in the murine model of fatal monocytic ehrlichiosis caused by systemic infection with virulent moncytic Ehrlichia (IOE). H&E staining shows extensive focal necrosis and apoptosis of hepatocytes (arrows). B) Hepatic histopathology in the murine model of mild monocytic ehrlichiosis caused by infection with mildly virulent Ehrlichia muris. H&E staining shows formation of well formed granuloma (arrowhead). (From Ismail N, Soong L, McBride JW, et al. Overproduction of TNF-alpha by CD8+ type 1 cells and down-regulation of IFN-gamma production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis. J Immunol, 2004; 172(3):1786–800. Permission granted.)