. Author manuscript; available in PMC: 2010 Jun 8.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2007 May 22;34(4):519–547. doi: 10.1007/s10928-007-9056-2

Table 1.

Parameter estimates for the time-variant reticulocyte residence time model (n = 5)

		Cellular Production Parameters			Residence Time Parameters

	E_max(g/dl/day)	EC₅₀(mU/ml)	k_e(1/day)	F_R	a_SS^* (day)	b(day)	τ₀(day)	τ_end(day)	τ_max^** (day)	τ_min^** (day)
Means	1.29	198	0.367	0.610	0.797	1.24	0.447	0.551^†	0.996^‡	0.306^‡
SD	0.471	83.0	0.112	0.0860	0.193	0.167	0.100	0.319	0.181	0.0990
MSE%	5.2%	5.3%	12.5%	12.5%	NA	2.8%	4.1%	4.5%	NA	NA

SD: Standard deviation

MSE%: Mean percent standard error

Secondary parameter

^**

Calculated value: the maximum or minimum determined τ(t) from time T₁ to T₂

^†

Not significantly different from τ₀ (P > 0.05)

^‡

Significantly different from τ₀ (P < 0.05)

NA: Not applicable